| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
atazanavir is a moderate inhibitor of CYP3A. atazanavir has not been evaluated in the literature showing its role of altering the activities of CYP1A2 and CYP2C9.
- Moderate inhibitors: ≥ 2-fold but < 5-fold AUC increase or ≥ 50% but < 80% decrease in clearance of in vivo CYP probe.
- Not evaluated in the literature: drugs implicated as inhibitors and inducers of CYP enzymes without reported clinical PK interaction studies.
Footnotes and References
|a.||assessment based on product information accessed via the Therapeutic Goods Administration of Australia Product and Consumer Medicines Information website ( https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI?OpenForm&t=PI&q=&r=https://www.ebs.tga.gov.au/ ).|
|b.||likely to be a major inhibitor based on subjective evaluation (≥ 2-fold AUC increase or ≥ 50% decrease in clearance of in vivo CYP probe).|
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