| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
doxepin is a moderate inhibitor of CYP2D6.
|Moderate inhibitors||cinacalcet  |
- Moderate inhibitors: ≥ 2-fold but < 5-fold AUC increase or ≥ 50% but < 80% decrease in clearance of in vivo CYP probe.
Footnotes and References
|1.||Harris RZ, Salfi M, Posvar E, Hoelscher D, Padhi D. Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl. European Journal of Clinical Pharmacology 2007; 63: 159-63.[PubMed]|
|2.||Szewczuk-Boguslawska M, Kiejna A, Beszlej JA, Orzechowska-Juzwenko K, Milejski P. Doxepin inhibits CYP2D6 activity in vivo. Polish Journal of Pharmacology 2004; 56: 491-94.[PubMed]|
|3.||Skinner MH, Kuan HY, Pan A, Sathirakul K, Knadler MP, Gonzales CR, Yeo KP, Reddy S, Lim M, Ayan-Oshodi M, Wise SD. Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clinical Pharmacology & Therapeutics 2003; 73: 170-77.[PubMed]|
|4.||Haefeli WE, Bargetzi MJ, Follath F, Meyer UA. Potent inhibition of cytochrome P450IID6 (debrisoquin 4-hydroxylase) by flecainide in vitro and in vivo. Journal of Cardiovascular Pharmacology 1990; 15: 776-79.[PubMed]|
|5.||Härtter S, Dingemanse J, Baier D, Ziegler G, Hiemke C. Inhibition of dextromethorphan metabolism by moclobemide. Psychopharmacology 1998; 135: 22-26.[PubMed]|
|6.||Steiner E, Dumont E, Spina E, Dahlqvist R. Inhibition of desipramine 2-hydroxylation by quinidine and quinine. Clinical Pharmacology & Therapeutics 1988; 43: 577-81.[PubMed]|
|7.||Madani S, Barilla D, Cramer J, Wang YB, Paul C. Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. Journal of Clinical Pharmacology 2002; 42: 1211-18.[PubMed]|
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