| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
ethinyl estradiol is a moderate inhibitor of CYP1A2.
|Moderate inhibitors||ethinyl estradiol  |
interferon alpha-2b 
- Moderate inhibitors: ≥ 2-fold but < 5-fold AUC increase or ≥ 50% but < 80% decrease in clearance of in vivo CYP probe.
Footnotes and References
|1.||Granfors MT, Backman JT, Laitila J, Neuvonen PJ. Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2[ast]. Clin Pharmacol Ther 2005; 78: 400-11.[PubMed]|
|2.||Islam M, Frye RF, Richards TJ, Sbeitan I, Donnelly SS, Glue P, Agarwala SS, Kirkwood JM. Differential Effect of IFNalpha-2b on the Cytochrome P450 Enzyme System: A Potential Basis of IFN Toxicity and Its Modulation by Other Drugs. Clinical Cancer Research 2002; 8: 2480-87.[PubMed]|
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