| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
grapefuit juice did not meet the criteria of being an inhibitor or inducer of CYP2D6.
|Criteria not met||chloroquine  |
grapefuit juice 
orange juice 
- Criteria not met: drugs evaluated in clinical PK interactions studies that do not meet the inclusion criteria (see Methods).
Footnotes and References
|1.||Masimirembwa CM, Gustafsson LL, Dahl ML, Abdi YA, Hasler JA. Lack of effect of chloroquine on the debrisoquine (CYP2D6) and S-mephenytoin (CYP2C19) hydroxylation phenotypes. British Journal of Clinical Pharmacology 1996; 41: 344-46.[PubMed]|
|2.||Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brosen K. Dose dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. European Journal of Clinical Pharmacology 1996; 51: 73-78.[PubMed]|
|3.||Szewczuk-Boguslawska M, Kiejna A, Grzesiak M, Beszlej JA, Chlebowska I, Orzechowska-Juzwenko K, Milejski P. The influence of clomipramine on CYP2D6 activity. Psychiatr Pol 2007; 41: 243-49.[PubMed]|
|4.||Ciraulo DA, Barnhill J, Boxenbaum H. Pharmacokinetic interaction of disulfiram and antidepressants. Am J Psychiat 1985; 142: 1373-74.[PubMed]|
|5.||Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein. Life Sci 2002; 71: 1149-60.[PubMed]|
|6.||Somer M, Kallio J, Pesonen U, Pyykko K, Huupponen R, Scheinin M. Influence of hydroxychloroquine on the bioavailability of oral metoprolol. British Journal of Clinical Pharmacology 2000; 49: 549-54.[PubMed]|
|7.||Sanz EJ, Bertilsson L. d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo. Therapeutic Drug Monitoring 1990; 12: 297-99.[PubMed]|
|8.||Bauer LA, Horn JR, Maxon S, Easterling TR, Shen DD, Strandness DE. Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver flood flow and drug disposition. Journal of Clinical Pharmacology 2000; 40: 533-43.[PubMed]|
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