PKIS v2.0 A clinical tool for identifying important pharmacokinetic drug-drug interactions
| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |

methoxsalen

  • methoxsalen did not meet the criteria of being an inhibitor or inducer of CYP1A2.
  • CYP1A2
    Criteria not metamiodarone [1]
    methoxsalen [2]
    zafirlukast [3]

    Footnotes and References

    1.Upton RA. Pharmacokinetic interactions between theophylline and other medication (Part I). Clinical Pharmacokinetics 1990; 20: 66-80.[PubMed]
    2.Apseloff G, Shepard DR, Chambers MA, Nawoot S, Mays DC, Gerber N. Inhibition and induction of theophylline metabolism by 8-methoxypsoralen. In vivo study in rats and humans. Drug Metabolism and Disposition 1990; 18: 298-303.[PubMed]
    3.Katial RK, Stelzle RC, Bonner MW, Marino M, Cantilena LR, Smith LJ. A drug interaction between zafirlukast and theophylline. Archives of Internal Medicine 1998; 158: 1713-15.[PubMed]
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