| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
pantoprazole did not meet the criteria of being an inhibitor or inducer of CYP2C19.
|Criteria not met||carbamazepine  |
- Criteria not met: drugs evaluated in clinical PK interactions studies that do not meet the inclusion criteria (see Methods).
Footnotes and References
|1.||Bertilsson L, Tybring G, Widen J, Chang M, Tomson T. Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19. British Journal of Clinical Pharmacology 1997; 44: 186-89.[PubMed]|
|2.||Gough PA, Curry SH, Araujo OE, Robinson JD, Dallman JJ. Influence of cimetidine on oral diazepam elimination with measurement of subsequent cognitive change. British Journal of Clinical Pharmacology 1982; 14: 739-42.[PubMed]|
|3.||Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ. Diazepam interaction with antituberculosis drugs. Clinical Pharmacology & Therapeutics 1981; 29: 671-78.[PubMed]|
|4.||Lefebvre RA, Flouvat B, Karolactamisier S, Moerman E, Vanganse E. Influence of lansoprazole treatment on diazepam plasma concentrations. Clinical Pharmacology & Therapeutics 1992; 52: 458-63.[PubMed]|
|5.||Gugler R, Hartmann M, Rudi J, Brod I, Huber R, Steinijans VW, Bliesath H, Wurst W, Klotz U. Lack of pharmacokinetic interaction of pantoprazole with diazepam in man. British Journal of Clinical Pharmacology 1996; 42: 249-52.[PubMed]|
|6.||Sanz EJ, Bertilsson L. d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo. Therapeutic Drug Monitoring 1990; 12: 297-99.[PubMed]|
|7.||Ishizaki T, Chiba K, Manabe K, Koyama E, Hayashi M, Yasuda S, Horai Y, Tomono Y, Yamato C, Toyoki T. Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation. Clinical Pharmacology & Therapeutics 1995; 58: 155-64.[PubMed]|
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