PKIS v2.0 A clinical tool for identifying important pharmacokinetic drug-drug interactions
| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |

verapamil

  • verapamil is a moderate inhibitor of CYP3A.
  • verapamil is a weak inhibitor of CYP1A2.
  • verapamil did not meet the criteria of being an inhibitor or inducer of CYP2D6.
  • CYP1A2CYP2D6CYP3A
    Moderate inhibitorsethinyl estradiol [1]
    interferon alpha-2b [2]
    cinacalcet [3]
    doxepin [4]
    duloxetine [5]
    flecainide [6]
    moclobemide [7]
    quinine [8]
    terbinafine [9]
    aprepitant [10]
    atazanavir [11]
    atazanavir/ritonavir [11]
    cimetidine [12]
    cyclosporine [13]
    diltiazem [14]
    fluconazole [15]
    fluvoxamine [16]
    imatinib [17]
    posaconazole [a]
    verapamil [14]
    Weak inhibitorscimetidine [18]
    clarithromycin [19]
    diltiazem [20]
    echinacea [21]
    erythromycin [19]
    mexiletine [22]
    moclobemide [23]
    norfloxacin [24]
    propranolol [25]
    roxithromycin [19]
    ticlopidine [26]
    verapamil [27]
    amiodarone [28]
    amitriptyline [29]
    aspirin [30]
    celecoxib [31]
    cimetidine [32]
    darifenacin [b]
    desvenlafaxine [33]
    diltiazem [34]
    diphenhydramine [35]
    escitalopram [36]
    felodipine [37]
    fluvoxamine [38]
    gefitinib [39]
    hydralazine [40]
    imatinib [41]
    interferon alpha-2b [2]
    ketoconazole [42]
    methadone [43]
    metoprolol [44]
    nortriptyline [45]
    oral contraceptives [46]
    oxprenolol [44]
    pindolol [44]
    propranolol [44]
    ranitidine [47]
    risperidone [48]
    ritonavir [49]
    saw palmetto [50]
    sertraline [51]
    timolol [44]
    venlafaxine [52]
    alprazolam [53]
    amiodarone [54]
    aspirin [30]
    azithromycin [55]
    bicalutamide [56]
    cimetidine [57]
    co-trimoxazole [58]
    cyclosporine [59]
    fluvoxamine [60]
    isoniazid [61]
    maraviroc [62]
    oral contraceptives [63]
    ranitidine [12]
    roxithromycin [64]
    simvastatin [65]
    Criteria not metamiodarone [66]
    methoxsalen [67]
    zafirlukast [68]
    chloroquine [69]
    citalopram [70]
    clomipramine [71]
    disulfiram [72]
    grapefuit juice [73]
    hydroxychloroquine [74]
    orange juice [73]
    propoxyphene [75]
    verapamil [76]
    amprenavir [c]
    buspirone [c]
    ciprofloxacin [d] [77]
    citalopram [c]
    darifenacin [c]
    darunavir/ritonavir [d] [c]
    dasatinib [c]
    efavirenze
    erlotinib [c]
    fosamprenavir [d] [78]
    nevirapine [c]
    nilotinib [c]
    omeprazole [c]
    oxcarbazepine [c]
    phenobarbitone [e] [79]
    propoxyphene [80]
    rifabutin [c]

    Footnotes and References

    a.assessment based on product information accessed via the Therapeutic Goods Administration of Australia Product and Consumer Medicines Information website ( https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI?OpenForm&t=PI&q=&r=https://www.ebs.tga.gov.au/ ).
    b.systemic preparations not available in Australia or New Zealand.
    c.clinical PK interaction studies referred to in product information.
    d.likely to be a major inhibitor based on subjective evaluation (≥ 2-fold AUC increase or ≥ 50% decrease in clearance of in vivo CYP probe).
    e.likely to be a major inducer based on subjective evaluation (≥ 2-fold decrease in AUC or ≥ 50% increase in clearance of in vivo CYP probe).
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    WARNING: While all efforts were put in to maintain the accuracy and currency of the information, it is possible that the knowledge and electronic tools may contain errors and inadequacy. Both Flinder's University and University of New South Wales are not liable to any damages or losses resulted from such circumstances. Clinical discretions are strongly advised at all times.