PKIS v2.0 A clinical tool for identifying important pharmacokinetic drug-drug interactions
| 1. Accepted major perpetrators | 2. Rejected perpetrators | 3. Unclassifiable | 4. Full table |
CYP1A2CYP2C9CYP2C19CYP2D6CYP3A
Weak inhibitorscimetidine [1]
clarithromycin [2]
diltiazem [3]
echinacea [4]
erythromycin [2]
mexiletine [5]
moclobemide [6]
norfloxacin [7]
propranolol [8]
roxithromycin [2]
ticlopidine [9]
verapamil [10]
amiodarone [11]
cimetidine [12]
co-trimoxazole [13]
disulfiram [14]
echinacea [4]
fluvastatin [15]
fluvoxamine [16]
ketoconazole [17]
lovastatin [11]
metronidazole [18]
sertraline [19]
simvastatin [11]
sulfadiazine [20]
voriconazole [21]
zafirlukast [a]
finasteride [22]
interferon alpha-2b [23]
ketoconazole [24]
omeprazole [25]
oral contraceptives [26]
roxithromycin [27]
amiodarone [28]
amitriptyline [29]
aspirin [30]
celecoxib [31]
cimetidine [32]
darifenacin [b]
desvenlafaxine [33]
diltiazem [34]
diphenhydramine [35]
escitalopram [36]
felodipine [37]
fluvoxamine [38]
gefitinib [39]
hydralazine [40]
imatinib [41]
interferon alpha-2b [23]
ketoconazole [42]
methadone [43]
metoprolol [44]
nortriptyline [45]
oral contraceptives [46]
oxprenolol [44]
pindolol [44]
propranolol [44]
ranitidine [47]
risperidone [48]
ritonavir [49]
saw palmetto [50]
sertraline [51]
timolol [44]
venlafaxine [52]
alprazolam [53]
amiodarone [54]
aspirin [30]
azithromycin [55]
bicalutamide [56]
cimetidine [57]
co-trimoxazole [58]
cyclosporine [59]
fluvoxamine [60]
isoniazid [61]
maraviroc [62]
oral contraceptives [63]
ranitidine [64]
roxithromycin [65]
simvastatin [66]
Weak inducerscarbamazepine [67]
lopinavir/ritonavir [68]
montelukast [69]
phenobarbitone [70]
smoking [71]
valproate [67]
aprepitant [a]
bosentan [a]
carbamazepine [72]
lopinavir/ritonavir [68]
aspirin [30]
ginko biloba [73]
carbamazepine [74]
phenobarbitone [75]
rifampicin [76]
aprepitant [77]
bosentan [78]
dexamethasone [79]
ginko biloba [80]
quinine [c]
smoking [81]
terbinafine [82]
No apparent change in clearanceamodiaquine [83]
aspirin [30]
omeprazole [84]
risperidone [48]
amodiaquine [83]
darifenacin [a]
modafinil [85]
omeprazole [86]
prednisone [87]
St John's wort [88]
amodiaquine [83]
levonorgestrel [89]
risperidone [48]
topiramate [90]
amodiaquine [83]
dexamethasone [91]
echinacea [4]
ginko-biloba [92]
maraviroc [93]
omeprazole [25]
smoking [94]
cimetidine [95]
echinacea [4]
finasteride [22]
fluoxetine [60]
gatifloxacin [96]
methylprednisolone [97]
paroxetine [98]
pioglitazone [66]
saw palmetto [50]
sertraline [99]
tenofovir [58]
tipranavir/ritonavir [100]
venlafaxine [101]
Not available in Australia or New Zealandarmodafinil
artemisinin
clinafloxacin
enoxacin
etintidine
furafylline
idrocilamide
methylcholanthrene
mibefradil
nafcillin
oltipraz
perfloxacin
phenylpropanolamine
pipemidic acid
rofecoxib
stiripentol
thiabendazole
troleandomycin
zileuton
azapropazone
benzbromarone
bucolome
indisulam
lornoxicam
miconazole [b]
nizatidine
oxandrolone
phenylbutazone
secobarbital
stiripentol
sulfamethizole
sulfaphenazole
sulfinpyrazone
armodafinil
artemisinin
norethindrone
clemastine
deramciclan
halofantrine
hydroxyzine
levomepromazine
melperone
mepyramine
mibefradil
midodrine
perphenazine
propafenone
quinidine
ranolazine
rofecoxib
stiripentol
thioridazine
tripelennamine
armodafinil
chloramphenicol [b]
clotrimazole [b]
conivaptan
diethyldithiocarbamate
mibefradil
miconazole [b]
nefazodone
nelfinavir
quinidine
stiripentol
sulfadimidine
sulfinpyrazone
telithromycin
tofisopam
troglitazone
troleandomycin

Footnotes and References

a.assessment based on product information accessed via the Therapeutic Goods Administration of Australia Product and Consumer Medicines Information website ( https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/PICMI?OpenForm&t=PI&q=&r=https://www.ebs.tga.gov.au/ ).
b.systemic preparations not available in Australia or New Zealand.
c.reported at Clinical Trials.gov ( http://clinicaltrials.gov/ct2/show/study/NCT00785486?sect=X701&view=results ).
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